New ISHLT Document on Risk Stratification in Pulmonary Arterial Hypertension

Published 05 September 2025
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A new ISHLT Document, ISHLT Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension, has been published in JHLT and is available to read online.

Led by Sandeep Sahay, MD, MSc and Raymond Benza, MD, this consensus document provides clinicians with a practical framework for the application of risk stratification systems in routine clinical practice along with future directions, thereby promoting evidence-based management and supporting efforts to improve patient outcomes.

Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by vascular remodeling and increased pulmonary vascular resistance, ultimately leading to right heart failure and premature death. Given the serious and life-limiting nature of the disease, accurate risk stratification is essential to guide therapeutic decision-making, identify patients at increased risk for clinical deterioration or mortality, and inform prognostic discussions. This consensus document reviews the key elements of contemporary risk tools individually and within the context of these multivariable tools to provide the reader with enough practical knowledge to apply these systems in daily practice.

Visit the Standards & Guidelines page for details, top takeaways, and links to read or download the document.