ISHLT Guidelines for the Management of Pediatric Heart Failure

Published 21 August 2025

Claire Irving, MBChB, MRCPCH, MD; Estela Azeka, MD; Rachele Adorisio, MD; Elizabeth Blume, MD; Carmel Bogle, MD; Henry Chubb, MBBS, PhD; Jennifer Conway, PharmD; Melissa Cousino, PhD; Jonathan Edelson, MD; Katrina Ford, BPharm, MSc; Paula Holinski, MD; Jan Janousek, MD, PhD; Ashwin Lal, MD; Teresa Lee, MD; Angela Lorts, MD, MBA; Stephanie Nakano, MD; David Rosenthal, MD; Joseph Rossano, MD; Shelley Miyamoto, MD.

J Heart Lung Transplant. August 2025.

• Advanced Heart Failure & Transplantation
• Cardiology
• Pediatrics
• Professional Guideline
• Publications & Journals
• Standards & Guidelines

Pediatric heart failure (HF) secondary to cardiomyopathies, acquired heart disease, and congenital heart disease (CHD) remains associated with significant morbidity and mortality. These guidelines represent an update from the International Society for Heart and Lung Transplantation guidelines for the management of pediatric HF that were published in 2014.

The purpose of this update is to incorporate advancements in pharmacologic therapies and new approaches in the evaluation and management of children with HF since the prior guideline publication. These guidelines are not intended for use in the management of HF related to left to right shunts and are primarily focused on the population of children with HF due to dysfunction of the myocardium.

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The ISHLT Perspective Piece is a new document type developed to accompany all ISHLT Documents and is specifically designed for print publication in JHLT. The piece The piece will set the context for the document in an easy-to-read manner and serves as an opportunity for writing groups to speak directly to the heart and lung transplant community about the rationale behind each document, its most important takeaways, and the hard work that went into creating it.