Looking Back on JHLT: The Podcast: Is Sotatercept Safe in Patients with PAH?
Published 15 July 2026
This month, JHLT: The Podcast is re-releasing a past audience favorite episode discussing the efficacy and safety of sotatercept in patients with PAH with Ioana Preston, MD, of Tufts University School of Medicine in Boston.
You can also stream the podcast on Spotify, Amazon, iTunes, and anywhere else you get podcasts.
This conversation explores:
- What makes sotatercept unique as the first “biologic” in the treatment of PAH
- Hypotheses about the mechanism of action in sotatercept
- Sotatercept’s interaction with mPAP and what it indicates about the drug’s action on the pulmonary vasculature
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you’re an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don’t already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

