New ISHLT Document on Antibodies and AMR in Heart Transplantation

Published 11 June 2025
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A new ISHLT Document,  Summary of the ISHLT Consensus Conference on Emerging Understanding of Antibodies and Antibody-Mediated Rejection in Heart Transplantation, has been published in JHLT and is available to read online! This document presents the findings and consensus statements from the April 2023 Consensus Conference on antibodies and AMR in heart transplant patients, led by Jon Kobashigawa and endorsed by ISHLT. The conference was held in conjunction with the 2023 Annual Meeting & Scientific Sessions in Denver, CO USA.

The understanding of circulating antibodies and their relationship to antibody-mediated rejection (AMR) has yet to be fully elucidated in heart transplantation. Although important in both pre- and post-transplant, it is not known what approach is optimal for treating these patients with circulating antibodies. The 2023 Consensus Conference represented a collaborative multidisciplinary effort by experts in cardiothoracic transplantation from across the world to understand and discuss the optimum approach and treatment of circulating antibodies and AMR in heart transplant candidates and recipients, and served as a forum to better understand the impact antibodies and AMR have on transplant patients

Visit the   Standards & Guidelines page for details, top takeaways, and links to read or download the document.