Ethical Considerations in Xenotransplantation of Thoracic Organs – A Call for a Debate on Value Based Decisions

Published 22 May 2024

Savitri Fedson, MD, MA; Jacob Lavee, ; Kelly Bryce, PhD; Tom Egan, MD, MSc; Anne Olland, MD, PhD; Manreet Kanwar, MD; Andrew Courtwright, MD, PhD; Are Martin Holm, MD, PhD.

J Heart Lung Transplantation, May 2024.

• Advanced Heart Failure & Transplantation
• Advanced Lung Failure & Transplantation
• Cardiothoracic Surgery
• Ethics
• Perspective
• Publications & Journals
• Standards & Guidelines

Xenotransplant covers a broad ethical territory and there are several ethical questions that have arisen in parallel with the technological advances that have allowed the first porcine transplants to occur. This brief communication highlights ethical considerations regarding heart and lung xenotransplantation, with an emphasis on unresolved value-based concerns in the field. The aim of this text is therefore to encourage the readers to consider the vast potential of this emerging technique to do good, but also the risk of doing harm, and to participate in a discussion. The list of questions presented here is not exhaustive but hopefully represents some of the questions that appear to be most pressing as the field advances. The focus is on the value-based, or ethical questions, not the questions related to the practical medical procedures.

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