ISHLT2026: Industry Symposia - Friday
24 April, 2026 11:45 a.m. to 12:45 p.m. EDT
CareDx | Natera | Traferox | Therakos (UK) Ltd | XVIVO

CareDx
Details coming soon
dd-cfDNA Beyond Rejection: Decoding Molecular Injury in Lung Transplantation
801A&B
Natera
dd-cfDNA Beyond Rejection: Decoding Molecular Injury in Lung Transplantation
Primary Core Therapy: Lung | Primary Practice Area: Pulmonology
Donor-derived cell-free DNA (dd-cfDNA) has become a valuable tool in lung transplant rejection surveillance, offering clinicians a high negative predictive value to confidently rule-out rejection in stable patients. As the field evolves, the role of cfDNA is expanding beyond rejection detection to encompass broader forms of allograft injury and potential early indicators of long-term outcomes. Emerging evidence on Extreme Molecular Injury (EMI) defined as dd-cfDNA% >5%, highlights its strong association with adverse post-transplant trajectories, including an increased risk of chronic lung allograft dysfunction (CLAD). This symposium will explore how routine dd-cfDNA monitoring provides meaningful, trendable insights into graft health, enabling a more proactive, outcomes-focused approach to patient management.
Moderator
Nirmal Sharma, MD, Baylor St. Luke's Medical Center, Houston, TX USA
Speakers
Holly Keyt, MD, UT Health San Antonio, San Antonio, TX USA
Present case demographics, pre-transplant and acute post-txp history
Fatima Anjum, MD, MHA, Temple Health, Philadelphia, PA USA
Didactic review of published literature on EMI, Temple data
Holly Keyt, MD, UT Health San Antonio, San Antonio, TX USA
Remainder of case presentation to include pt's dd-cfDNA paired with PFTs and current clinical status, review practice changes implemented since
Jason Li, Mount Sinai, New York, NY USA
Review of Mt. Sinai protocol for treatment of dd-cfDNA elevated in the absence of AR or infection, case studies
Reaching 200 Transplants per Year: How Improved Preservation Can Drive Outcomes & Volume in Lung & Heart Programs
Room 718B
Traferox
Reaching 200 Transplants per Year: How Improved Preservation Can Drive Outcomes & Volume in Lung & Heart Programs
Primary Core Therapy: Lung | Primary Practice Area: Cardiothoracic Surgery
10°C organ preservation is redefining what is possible in heart and lung transplantation by improving organ protection, simplifying logistics, and offering a more scalable approach to improved preservation. This symposium will explore the underlying science and mechanisms supporting 10°C preservation, review the growing body of clinical evidence in heart and lung preservation, and consider how improved preservation strategies can unlock higher transplant volumes – creating a path to 200 heart and 200 lung transplants per year.
Moderator
Shaf Keshavjee, MD, MSc, FRCSC, FACS, University Health Network, Toronto, ON Canada
Ashish Shah, MD, FACS, Vanderbilt University Medical Center, Nashville, TN USA
Program
Introduction
Shaf Keshavjee, MD, MSc, FRCSC, FACS, University Health Network, Toronto, ON Canada
Ashish Shah, MD, FACS, Vanderbilt University Medical Center, Nashville, TN USA
10°C Preservation: The Science and Mechanisms Behind Improved Preservation
Marcelo Cypel, MD, MSc, FACS, FRCSC, University Health Network, Toronto, ON Canada
10°C Lung Preservation: Clinical Trials and Experience
Konrad Hoetzenecker, MD, PhD, MIB, Vanderbilt University Medical Center, Nashville, TN USA
Improved Outcomes & Logistics: Experience with >140 Hearts Preserved at 10°C
Aaron Williams, MD, Vanderbilt University Medical Center, Nashville, USA
Closing Remarks: Reaching 200 Lung & 200 Heart Transplants a Year
Shaf Keshavjee, MD, MSc, FRCSC, FACS, University Health Network, Toronto, ON Canada
Ashish Shah, MD, FACS, Vanderbilt University Medical Center, Nashville, TN USA
Q&A
Modern Transplant Care: Early Intervention Approaches for Allograft Protection
Room 714-716
Therakos (UK) Ltd
Modern Transplant Care: Early Intervention Approaches for Allograft Protection
Primary Core Therapy: Lung | Primary Practice Area: Research & Immunology
Explore how advances in immunobiology, clinical research, and real‑world data are reshaping early intervention strategies for allograft injury and rejection in cardiothoracic transplantation, with the aim of improving long‑term graft function and patient outcomes.
Moderator
Stephen Juvet, MD, PhD, University Health Network, Toronto, ON Canada
Program
From Injury to Immune Reset: Translational Insights Into Allograft Immunobiology in 2026
Andrew Gelman, PhD, Washington University School of Medicine, St. Louis, MO USA
Heart Allograft Protection in 2026: Early Intervention to Improve Long‑Term Outcomes
Andreas Zuckermann, MD, Medical University of Vienna, Vienna, Austria
Lung Allograft Protection in 2026: Early Intervention to Improve Long‑Term Outcomes
Andrew Fisher, FRCP, PhD. Newcastle University, Newcastle upon Tyne, United Kingdom
New HOPE for All Hearts - Clinical Evidence for HOPE across DBD, DCD, ECD, and Pediatric Transplantation
Room 808
XVIVO
New HOPE for All Hearts - Clinical Evidence for HOPE across DBD, DCD, ECD, and Pediatric Transplantation
Primary Core Therapy: Heart | Primary Practice Area: Cardiothoracic Surgery
With more than 500 cases performed worldwide, Hypothermic Oxygenated Perfusion (HOPE) for hearts has been applied in a broad range of donor types, from standard to extended-criteria donors, and from adult to pediatric hearts, including both DBD and DCD – demonstrating its potential to change the paradigm of heart preservation.
Join us for this symposium where leading experts will share the latest clinical evidence and real-world experiences using HOPE in heart transplantation. The session will highlight pivotal findings from the U.S. PRESERVE trial in extended criteria donor hearts, alongside results from the HOPE at Heart trial evaluating direct procurement and hypothermic oxygenated perfusion in DCD hearts. Attendees will also learn about early experience using HOPE in pediatric DCD transplantation. Together, these data and clinical experiences illustrate how HOPE is being applied across all donor heart types – shaping a new paradigm in heart preservation.
Moderators
Joshua Chan, MD, Emory University School of Medicine, Atlanta, GA USA
Guillaume Lebreton, MD, PhD, Hôpital La Pitié Salpêtrière, Paris, France
Program
Rewriting the Rules of Donor Heart Preservation: A Focus on Extended Criteria Donors in the PRESERVE Clinical Trial
Victor Pretorius, MD, Emory University School of Medicine, Atlanta, GA USA
Direct Procurement and HOPE in DCD Transplantation: Insights from HOPE at Heart, a Prospective, Multicenter and Multinational Clinical Trial
Filip Rega, MD, PhD, University Hospitals Leuven, Leuven, Belgium
HOPE: The Solution for Pediatric DCD Heart Transplantation
Louise Kenny, MD, Freeman Hospital, Newcastle Upon Tyne, United Kingdom





