Xenotransplantation–Crossing the Final Frontier?

Wednesday, 25 May, 2022, 12:00 – 1:15 p.m. EDT

The recently performed heart transplantation using a genetically modified pig heart into an adult recipient has catapulted the discussion around xenotransplantation back on the center stage. After decades of research and grown understanding and ability to overcome interspecies differences in animal models, have we now reached the point to justify xenotransplantation into humans?

The session will provide insight into the challenges encountered, the genetic manipulations undertaken to overcome these, surgical concerns and solutions, insight into the clinical course of human xenotransplantation in present and past and discussion around ethical and infectious concerns.

Scientific Program

Meyer_Anna_Square_100px_2213125.png Anna Meyer, MD
Heidelberg University Hospital
Heidelberg, Germany
Urschel_Simon_Square_100px_2213126.jpg Simon Urschel, MD, PhD
University of Alberta
Edmonton, AB Canada

Pierson_Richard_100px_2199553.jpg Of Mice and Men: Genetic Engineering to Overcome Interspecies Barriers
Richard Pierson, MD
, Massachusetts General Hospital, Boston, MA, USA
This presentation will discuss natural incompatibilities (αGAL and other polysaccharides, complement regulating and antithrombotic factors, immune activation molecules) that have been identified over the decades of xenotransplant and (successful) efforts to address them with novel techniques such as somatic cell nuclear transfer and gene insertion with CRISPR/CAS9.
Brenner_Paolo_2213134.png Is the Solution the Solution? Organ Preservation and Surgical Aspects of Xenotransplantation
Paolo Brenner, MD
, Ludwig-Maximilians-University, Munich, Germany
The success of xenotransplantation also depends on surgical considerations for animal selection, graft explantation and preservation, the perfusion solution and strategies. This presentation will address these questions including a potential role of ex-vivo perfusion.
Mohiuddin_Muhammad_2213128.jpg Perioperative Management of a Xenotransplant
Muhammad M. Mohiuddin, MD
, University of Maryland School of Medicine, Baltimore, MD, USA
Do we have to think outside the species? In this presentation specific considerations around immune suppression and growth inhibition will be addressed and the reasons for divergence from standard protocols for inter-human transplantation explained.
Fishman_Jay_2213131.jpg Are We Any Smarter After the Pandemic? Risk and Prevention of Interspecies Infectious Transmission in Xenotransplantation
Jay Fishman, MD
, Massachusetts General Hospital, Boston, MA, USA
This presentation will address concerns about transmission of infectious diseases from the donor species to the human recipient, the potential of generation of novel infectious agents due to interspecies exchange and recombination and the strategies to minimize infectious risks in the setting of xenotransplantation.
Chinnock_Richard_2213132.jpg 38 Years After Baby Fae: Ethical Consideration Around Xenotransplantation and Associated Gene Manipulation
Richard Chinnock, MD, MHCM
, Loma Linda University Children's Hospital, Loma Linda, CA, USA
Ethical considerations around manipulating animals to become better suitable “spare part” providers for humans, emotional aspects of receiving an animal organ and specific aspects of xenotransplantation for children and infants will be discussed by the cardiologist working for 3 decades with the pioneer of infant heart transplant and performer of the thus far only baboon into human transplantation.

Additional Panel Discussants:
Marckmann_Georg_100px_2226579.jpeg Georg Marckmann, MD, MPH
Ludwig-Maximilians-University Munich
Munich, Germany
Bruno Reichart
Bruno Reichart, MD
Munich, Germany
Andreas Zuckermann
Andreas Zuckermann, MD
Medical University of Vienna
Vienna, Austria

Continuing Education Information

There will be no continuing education available for this webinar.