Visit the ISHLT2019 Online Program Viewer to see the full abstracts from this session

Pathology (Hibiscus 2)
(BSTR, PATH)   Poster Numbers: 605

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Primary Audience: PATH
Secondary Audiences: BSTR, LF/LTX, PEDS

Session Summary: Clinical and pathologic definitions for chronic rejection in lung transplantation - antibody-mediated rejection (AMR) and chronic lung allograft dysfunction (CLAD) - have undergone rapid changes over the past decade. This session will provide an update on the two major areas of discussion and acquisition over the recent years (AMR, CLAD) and potential areas for future development.

Chairs: Monique Malouf, MD and Desley Neil, FRCPath
 

7:00 AM	Clinical Review of Antibody Mediated Rejection and Chronic Lung Allograft Dysfunction Navin K. Kapur, MD, Tufts Medical Center, Boston, MA, USA
7:15 AM	Pathology of Antibody Mediated Rejection Fiorella Calabrese, MD, University of Padua, Padua, Italy
7:30 AM	Pathology of Chronic Lung Allograft Dysfunction David M. Hwang, MD, PhD, Toronto General Hospital, Toronto, ON, Canada
7:45 AM	15-min Panel Discussion

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Primary Audience: PATH
Secondary Audiences: BSTR, HTX, LTX, PEDS

Chairs: Patrick Bruneval, MD and Brandon T. Larsen, MD, PhD
 

8:00 AM	(114) Gene Expression in Formalin-Fixed Paraffin-Embedded Lung Transplant Biopsies: Correlation between Molecular and Histologic Phenotypes B. Adam, K. Du, S. Rotich, M. Mengel. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
8:15 AM	(115) Occurrence and Risk Factors for Acute Lung Injury (ALI) and Organizing Pneumonia (OP) after Lung Transplant E. N. Pavlisko1, M. L. Neely1, H. Kopetskie2, D. Hwang3, C. F. Farver4, A. V. Arrossi4, W. D. Wallace5, P. Illei6, M. Sever7, J. Kirchner1, C. W. Frankel1, L. D. Snyder1, T. Martinu8, M. Y. Shino9, N. Williams10, M. A. Robien11, L. G. Singer8, M. Budev4, W. Tsuang4, P. D. Shah6, J. M. Reynolds1, S. Weigt9, J. A. Belperio9, S. M. Palmer1, J. L. Todd1. 1Duke University Medical Center, Durham, NC, 2Rho Federal Systems Division, Chapel Hill, NC, 3Sunnybrook Health Sciences Center, Toronto, ON, Canada, 4Cleveland Clinic, Cleveland, OH, 5University of California, Los Angeles, CA, 6Johns Hopkins University, Baltimore, MD, 7Rho Federal Systems Division, Chapal Hill, NC, 8University of Toronto, Toronto, ON, Canada, 9University of California Los Angeles, Los Angeles, CA, 10National Institute of Allergy and Infectious Disease, Bathesda, MD, 11National Institute of Allergy and Infectious Disease, Bethesda, MD
8:30 AM	(116) The Prognostic Value of Fibrin and Organizing Pneumonia in Transbronchial Biopsies from Lung Transplant Patients A. Vanstapel1, S. E. Verleden1, A. Van Herck1, J. Kaes1, T. Heigl1, A. Sacreas1, E. Verbeken2, B. Weynand2, B. M. Vanaudenaerde1, G. M. Verleden1, R. Vos1. 1Leuven Lung Transplant Unit, KU Leuven - UH Leuven, Leuven, Belgium, 2Department of Imaging and Pathology, KU Leuven - UH Leuven, Leuven, Belgium
8:45 AM	(117) Sarcoidosis Associated Pulmonary Hypertension: Correlation of Vascular Morphologic Changes with Hemodynamic Data in Explanted Lungs P. Chung, K. Warrior, M. Reid, R. Nigdelioglu, S. Boyes, V. Ananthanarayanan, S. Quddus. Pulmonary and Critical Care, Loyola University Medical Center, Maywood, IL
9:00 AM	(118) What are the Histopathologic Findings in Pulmonary Allografts with Graft Failure? R. E. White, A. P. Burke. Pathology, University of Maryland, Baltimore, MD
9:15 AM	(119) Endomyocardial Biopsy Findings in Pediatric Heart Transplants Recipients with Positive HLA Associated Antibodies: Review of a Cohort with Poor Outcomes A. Shenoy1, A. K. Esnakula2, S. S. Goldstein2, B. A. Pietra3, M. S. Bleiweis3, F. J. Fricker3, D. Gupta3. 1Departments of Pathology, Immunology and Laboratory Medicine & Pediatrics, University of Florida, Gainesville, FL, 2Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 3Congenital Heart Center, University of Florida, Gainesville, FL
9:30 AM	(120) Accelerated Cardiac Allograft Vasculopathy: A Clinical and Pathologic Correlation Study D. V. Miller1, M. Revelo1, E. Hammond1, B. Kfoury2, K. Afshar2, K. Molina3, R. Alharethi2. 1Pathology, UTAH Cardiac Transplant Program, Salt Lake City, UT, 2Cardiology, UTAH Cardiac Transplant Program, Salt Lake City, UT, 3Pediatric Cardiology, UTAH Cardiac Transplant Program, Salt Lake City, UT

Visit the ISHLT2019 Online Program Viewer to see the full details for this session

Primary Audience: PATH
Secondary Audiences: HF/HTX, LF/LTX

Session Summary: The postmortem examination ("autopsy") is underutilized in modern medicine, but provides critical information to the clinicians, families and loved ones of the decedent to help them understand the decedent's clinical course. Data obtained from autopsies may be used by hospital quality personnel, researchers, policy makers, registries and device manufacturers to improve the state of thoracic transplantation and mechanical circulatory support therapy.

Chairs: Lorriana E. Leard, MD and Carmela Tan, MD
 

10:15 AM	The Autopsy in the Modern Era: What the Clinician Still Would Like to Gain from an Autopsy Stephen C. Clark, MD, Freeman Hospital, Newcastle Upon Tyne, UK
10:30 AM	What the Pathologist Can Tell: More Than Just Cause of Death Anja C. Roden, MD, Mayo Clinic, Rochester, MN, USA
10:45 AM	How is a Postmortem Examination Performed: Frequently Asked Questions Billie S. Fyfe-Kirschner, MD, Robert Wood Johnson School of Medicine, New Brunswick, NJ, USA
11:00 AM	The Autopsy in the Mechanical Circulatory Support Patient Robert F. Padera, MD, PhD, Brigham & Women's Hospital, Boston, MA, USA
11:15 AM	The Autopsy in the Thoracic Transplant Patient Ornella Leone, MD, S. Orsola Hospital, Bologna, Italy
11:30 AM	The ‘Rapid Autopsy’: A Tool for Scientific Inquiry Dylan V. Miller, MD, Intermountain Central Lab, Murray, UT, USA
11:45 AM	15-min Panel Discussion