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Primary Audience: BSTR
Secondary Audience: LTX, PEDS, PATH

Chairs: Marilia Cascalho, MD, PhD and Matthew G. Hartwig, MD
 

10:30 AM	(5) Early Detection of Post-Transplant Lymphoproliferative Disorder Using Circulating Tumor DNA J. Soo, J. Schroers-Martin, A. Garofalo, D. Kurtz, N. D'Emilio, H. Luikart, A. Alizadeh, K. Khush. Stanford University, Stanford, CA
10:45 AM	(6) Distinct Heart Failure Phenotypes Identified by Myocardial Transcriptome Sequencing: Targets for Reverse Remodeling P. Shah1, W. Zhu2, S. Navankasattusas3, D. K. Ramadurai3, S. S. Desai1, I. Taleb3, I. Efimov4, R. Singh5, N. Aliyev3, R. K. Iyer2, O. Wever-Pinzon6, S. McKellar7, W. T. Caine8, C. R. deFilippi9, J. Zhu10, S. Drakos6. 1Heart Failure and Transplantation, Inova Heart and Vascular Institute, Falls Church, VA, 2Inova Translational Medicine Institute, Falls Church, VA, 3University of Utah, Salt Lake City, UT, 4George Washington University, Washington, DC, 5Cardiac Surgery, Inova Heart and Vascular Institute, Falls Church, VA, 6Heart Failure and Transplantation, University of Utah, Salt Lake City, UT, 7Cardiac Surgery, University of Utah, Salt Lake City, UT, 8Cardiac Surgery, Intermountain Medical Center, Salt Lake City, UT, 9Inova Heart and Vascular Institute, Falls Church, VA, 10Mokobio, Rockville, MD
11:00 AM	(315) Exosome Proteomics and Machine Learning Identify Novel Biomarkers of Primary Graft Dysfunction N. Giangreco1, G. Lebreton2, S. Restaino3, M. Farr3, P. C. Colombo3, E. Zorn4, N. Tatonetti1, P. Leprince2, J. Kobashigawa5, B. Fine3. 1Biomedical Informatics, Columbia University, New York, NY, 2Chirurgie Thoracique et Cardiovasculaire, Pitié-Salpêtrière University Hospital, Paris, France, 3Division of Cardiology, Columbia University, New York, NY, 4Center for Translational Immunology, Columbia University, New York, NY, 5Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
11:15 AM	(8) Engineered Mesenchymal Stromal Cell Therapy during Pig Ex Vivo Lung Perfusion and Transplant A. I. Nykanen1, A. Mariscal1, M. Takahashi1, A. Duong1, A. Ali1, M. Chen1, A. Takahagi1, H. Gokhale1, C. Estrada2, T. Martinu1, S. Juvet1, J. Yeung1, T. K. Waddell1, M. Cypel1, M. Liu1, J. E. Davies3, S. Keshavjee1. 1Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, 2Tissue Regeneration Therapeutics, Toronto, ON, Canada, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
11:30 AM	(9) Hydrogen-Rich Preservation Solution Attenuates Lung Ischemia-Reperfusion Injury after Prolonged Cold Ischemia in a Canine Left Lung Transplant Model H. Kayawake1, T. F. Chen-Yoshikawa1, M. Saito1, S. Hirano2, R. Kurokawa2, H. Yamagishi1, R. Okabe1, F. Gochi1, J. Tokuno1, S. Ueda1, Y. Yokoyama1, M. Ikeda1, H. Oda1, Y. Yamada1, Y. Yutaka1, D. Nakajima1, A. Ohsumi1, M. Hamaji1, H. Date1. 1Department of Thoracic Surgery, Kyoto University, Kyoto, Japan, 2MiZ Company Limited, Kamakura, Japan
11:45 AM	(10) Atorvastatin Preserves Cardiac Contractility via Reducing Matrix Metalloproteinase-2 Isoforms Expression in a Diabetic Heart Model H. Lee1, S. Lee1, S. Song2, S. Bae3, S. Kim4, J. Choi5. 1Cardiology Department, Pusan National University Hospital, Busan, Korea, Republic of, 2Nephrology Department, Pusan National University Hospital, Busan, Korea, Republic of, 3MRC for Ischemic Tissue Regeneration and Department of Pharmacology, Medical Research Institute, Pusan National University Hospital, Busan, Korea, Republic of, 4Endocrinology Department, Pusan National University Hospital, Busan, Korea, Republic of, 5Department of Cardiology, Pusan National University Hospital, Busan, Korea, Republic of
12:00 PM	(11) Triptolide Attenuates Graft Inflammation During Ex Vivo Lung Perfusion S. Burki, K. Noda, B. Philips, P. G. Sanchez, A. Kumar, J. D'Cunha. Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

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Primary Audience: BSTR
Secondary Audience: HF/HTX, LF/LTX

Session Summary: The goal of this symposium is to review advances in molecular diagnostic assessments and novel biomarkers in thoracic (both heart and lung) organ transplantation. This will include approaches that are being applied clinically and others that are investigational but that can provide greater insight into the pathophysiology and immunology of allograft rejection.

Chairs: Daniel Kreisel, MD, PhD and Tereza Martinu, MD
 

2:00 PM	Donor-Derived Cell Free DNA as a Marker of Allograft Injury Hannah Valantine, MD, National Institutes of Health, Bethesda, MD, USA
2:15 PM	Q&A
2:20 PM	Monitoring Immune Responses Glen Westall, MD, PhD, Alfred Hospital, Melbourne, Australia
2:35 PM	Q&A
2:40 PM	MicroRNA and Exosomes P. Christian Schulze, MD, PhD, University Hospital, Jena, Germany
2:55 PM	Q&A
3:00 PM	Through the Looking Glass: Advances in Histology Martin Goddard, FRCS, MRCPa, Papworth Hospital, Cambridge, UK
3:15 PM	Q&A
3:20 PM	Gene Expression Signatures to Monitor Graft Rejection Jean-Paul Duong Van Huyen, MD, Hospital Necker, Paris, France
3:35 PM	Q&A

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Primary Audience: BSTR
Secondary Audience: HTX, LTX, PATH

Chairs: Fabio Ius, MD and Thalachallour Mohanakumar, PhD
 

4:15 PM	(72) 31 Day Xeno Lung Recipient Survival - Progress towards the Clinic L. Burdorf1, C. Laird2, S. Sendil2, N. O'Neill2, T. Zhang2, D. Parsell2, I. Tatarov3, Z. Abady1, B. M. Cerel1, S. Pratts1, C. J. Phelps4, D. L. Ayares4, A. M. Azimzadeh1, R. N. Pierson III1. 1Surgery, Center for Transplantation Sciences, MGH, Charlestown, MA, 2Surgery, University of Maryland, Baltimore, MD, 3Surgery, University of Maryland, Baltimore, MA, 4Revivicor, Blacksburg, VA
4:30 PM	(73) Tolerance Induction by Myeloid Progenitor Cells Does Not Require Lethal Preconditioning or Hematopoietic Stem Cell Transplantation Y. Li1, A. Sedello2, J. Domen1. 1Ward Family Heart Center, Children's Mercy Hospital and Clinics, Kansas City, MO, 2Cellerant Therapeutics, San Carlos, CA
4:45 PM	(74)IL-22 Regulates Induction of Foxp3-Rich Tertiary Lymphoid Organs in Tolerant Lung Allografts S. Tanaka1, J. M. Gauthier1, A. Fuchs1, W. Li1, R. Higashikubo1, A. Y. Tong1, A. S. Krupnick2, A. E. Gelman1, D. Kreisel1. 1Department of Surgery, Washington University in St. Louis, St. Louis, MO, 2Department of Surgery, The University of Virginia, Charlottesville, VA
5:00 PM	(75) Intrapulmonary Immune Regulation by Pre-Transplant Infusion of Recipient-Derived Regulatory T Cells in a Rat Model of Ex Vivo Lung Perfusion Followed by Transplantation E. Miyamoto, T. Martinu, D. Hwang, A. Ohsumi, K. Boonstra, B. Joe, M. Umana, M. Liu, M. Cypel, S. Keshavjee, S. Juvet. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada
5:15 PM	(76) PI3-Kinase Inhibition Promotes Tolerogenic CD8+ T Cell Function in Lung Transplant Recipients with a History of Cigarette Smoke Exposure K. J. Patel1, Q. Cheng2, D. P. Allen1, C. Li1, C. Wallace1, A. Alawieh1, L. Cardenas3, J. Kilkenny1, S. N. Nadig1, M. Goddard4, J. Christie5, C. Krieg3, C. Atkinson1. 1Surgery, Medical University of South Carolina, Charleston, SC, 2Department of Surgery, Tongji Hospital, Wuhan, China, 3Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 4Pathology, Royal Papworth Hospital NHS Trust, Cambridgeshire, United Kingdom, 5Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
5:30 PM	(77) Donor T and NK Cells are Derived from the Donor Lung Parenchyme and Represent Tissue-Resident Memory Cells - An Important Feature for Tolerance Development R. Bellmàs Sanz1, A. Hitz1, B. Wiegmann2, K. Bläsing1, F. Ius2, A. Knöfel2, I. Tudorache2, M. Avsar2, D. Jonigk3, A. Haverich2, G. Warnecke2, C. Falk1. 1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Institute of Pathology, Hannover Medical School, Hannover, Germany
5:45 PM	(78) Cardiac Allograft Vasculopathy is Linked to Impaired Generation of Regulatory M2 Macrophages L. Holzhauser, T. Imamura, K. A. Arnold, A. Schroeder, C. Murks, J. Powers, T. Riley, G. Kim, J. Raikhelkar, B. Smith, A. Nguyen, S. Nathan, B. Chung, V. Jeevanandam, N. Narang, I. Ebong, G. Sayer, N. Uriel, A. Francis. University of Chicago, Chicago, IL

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Basic Science & Translational Research (Hibiscus 1 & 2)
(BSTR)   Poster Numbers: 573-604, 606-634

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Primary Audience: BSTR
Secondary Audience: HTX, LTX, PATH

Chairs: Yoshito Yamada, MD, PhD and Sebastian G. Michael, MD
 

6:15 PM	(357) Downregulation of Alloimmunity in Lung Allograft by Eosinophils is Orchestrated by PD-L1 Dependent Contact with CD8+ T Cells O. O. Onyema1, Y. Guo1, B. Mahgoub1, A. Manafi1, Q. Wang1, S. Criswell2, J. Lannigan3, E. A. Jacobsen4, A. E. Gelman5, D. Kreisel5, A. S. Krupnick1. 1Department of Surgery and Carter Immunology Center, University of Virginia, Charlottesviile, VA, 2Department of Cell Biology and Advanced Microscopy Core Laboratory, University of Virginia, Charlottesviile, VA, 3Flow Cytometry Core Facility, University of Virginia, Charlottesviile, VA, 4Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ, 5Department of Surgery, Washington University, St Louis, MO
6:20 PM	(358) Donor-Derived Factors Influence NK Cell Effector Activity in a Model of Antibody-Mediated Chronic Rejection C. M. Lin1, B. Mehrad1, R. G. Gill2. 1Medicine, University of Florida, Gainesville, FL, 2Surgery, University of Colorado, Aurora, CO
6:25 PM	(359) Proteomic Profiling of Extracellular Vesicles during Acute Cellular Rejection O. Gidlöf, I. Sukma Dewi, J. Öhman, M. Evander, T. Laurell, G. Smith. Lund University, Lund, Sweden
6:30 PM	(360) Recipient CD103+ Classical Dendritic Cells Enhance Acute Rejection in Response to Airway Inflammation after Mouse Lung Transplantation T. Watanabe, T. Martinu, K. Boonstra, J. M. Umana, M. Horie, Z. Guan, D. Hwang, M. Liu, S. Keshavjee, S. Juvet. University Health Network, Toronto, ON, Canada
6:35 PM	(361) Development of Novel Murine Antibody Mediated Rejection Model after Orthotopic Lung Transplant Y. Shiina, H. Suzuki, T. Kaiho, A. Hata, T. Yamamoto, J. Morimoto, Y. Sakairi, H. Wada, T. Nakajima, I. Yoshino. Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
6:40 PM	(362) Recipient HLA-G Single Nucleotide Polymorphisms Predict Post-Lung Development of Donor Specific Antibodies D. C. Birriel, A. Ulahannan, J. Ma, J. Lazarte, T. Martinu, L. Singer, V. Rao, S. Keshavjee, D. Delgado, J. Tikkanen, S. Juvet. UHN, Toronto, ON, Canada
6:45 PM	(363) Alpha1-Antitrypsin Therapy Suppresses Acute Rejection in an Orthotopic Murine Lung Transplantation Model T. Nakagiri1, A. Knöfel1, S. Janciauskiene2, P. Zardo1, S. Wrenger2, T. Welte2, A. Haverich1, G. Warnecke1. 1Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany, 2Respiratory Medicine, Hannover Medical School, Hannover, Germany
6:50 PM	(364) Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Responses to Lung Self-Antigens Precedes Histological Evidence of Chronic Rejection Following Orthotopic Murine Lung Transplantation M. Rahman, M. Sharma, W. Liu, M. A. Smith, R. M. Bremner, T. Mohanakumar. Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
6:55 PM	(365) Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation B. O'Sullivan1, J. Powell2, S. Lukowski3, M. Tan1, P. Hopkins1, D. Chambers1. 1Queensland Lung Transplant Research, Brisbane, Australia, 2Garvan Institute, Sydney, Australia, 3Institute for Molecular Bioscience, Brisbane, Australia
7:00 PM	(366) Clonal Composition and Single-Cell Characterization of T-Cell Infiltrates in Cardiac Allograft Vasculopathy M. V. Habal1, A. Myung2, S. Rao2, S. See2, R. R. Shihab2, P. Roy2, C. Marboe3, S. Restaino1, A. S. Han2, M. Givertz4, J. C. Madsen5, L. J. Addonizio6, M. Farr1, E. Zorn2. 1Cardiology, Columbia University, New York, NY, 2Columbia Center for Translational Immunology, Columbia University, New York, NY, 3Pathology & Cell Biology, Columbia University, New York, NY, 4Cardiology, Brigham and Women's Hospital, Boston, MA, 5Surgery, Massachusetts General Hospital, Boston, MA, 6Pediatric Cardiology, Columbia University, New York, NY
7:05 PM	(367) The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung C. Falk1, B. Wiegmann2, A. Hitz1, R. Bellmas-Sanz1, K. Bläsing1, F. Ius2, C. Kühn2, M. Avsar2, I. Tudorache2, A. Haverich2, G. Warnecke2. 1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
7:10 PM	(368) Persisting Donor Alveolar Macrophages Have Increased Expression of Scavenger Receptor CD206 Compared to Graft-Infiltrating Recipient-Derived Macrophages Following Lung Transplantation M. E. Snyder1, S. P. Weisberg2, T. Connors3, L. Benvenuto4, L. Shah4, H. J. Robbins4, J. L. Hook4, F. D'Ovidio5, J. Sonett5, S. Arcasoy4, D. L. Farber5. 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Pathology, Columbia University, New York, NY, 3Pediatrics, Columbia University, New York, NY, 4Medicine, Columbia University, New York, NY, 5Surgery, Columbia University, New York, NY

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Primary Audience: BSTR
Secondary Audience: HTX, LTX, PATH

Chairs: Andrew E. Gelman, PhD and Frank D'Ovidio, MD, PhD
 

1:45 PM	(156) Mitochondrial DNA Mismatches in Thoracic Transplantation: Potential Triggers of Allograft Immunogenicity A. Marishta1, Y. Yang1, X. Hu2, M. Jang1, K. Cuttin1, A. Jackson3, H. Luikart4, K. Bhatti1, U. Fideli1, T. Deuse2, K. Khush4, S. Schrepfer2, S. Agbor-Enoh1, H. Valantine1. 1Genomic Research Alliance for Transplantation (GRAfT), Laboratory of Transplantation Genomics, National Heart, Lung, and Blood Institute, Bethesda, MD, 2Department of Surgery, Transplant and Stem Cell Immunobiology (TSI)-Lab, University of California San Francisco (UCSF), San Francisco, CA, 3Pulmonary and Critical Care Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, 4Department of Medicine, Stanford University School of Medicine, Palo Alto, CA
2:05 PM	(157) Effects of Nissen Fundoplication on Markers of Microaspiration and Inflammation after Lung Transplantation K. C. Zhang1, S. E. Hunter1, E. Huszti2, M. Ahmed1, L. Levy1, K. M. Boonstra1, A. T. Sage1, S. Azad1, R. Zamel1, C. Frankel3, M. Budev4, P. Shah5, L. D. Snyder3, J. Belperio6, L. G. Singer1, S. S. Weigt6, J. L. Todd3, S. Keshavjee1, S. M. Palmer3, T. Martinu1, *. for the CTOT-20 Investigators1. 1Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, 2Biostatistics Research Unit, University Health Network, Toronto, ON, Canada, 3Duke University Medical Center, Durham, NC, 4Cleveland Clinic, Cleveland, OH, 5Johns Hopkins University Hospital, Baltimore, MD, 6UCLA Medical Center, Los Angeles, CA
2:25 PM	(158) ABO Tolerance Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes J. Fersovich1, B. Motyka1, I. Adam1, J. Pearcey1, K. Tao1, C. W. Cairo2, P. J. Cowan3, L. J. West1. 1Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, AB, Canada, 2Dept Chemistry, University of Alberta, Edmonton, AB, Canada, 3Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
2:45 PM	(159) Modulating Mitochondrial Fusion/Fission Induces Immunoprotective Effects in Models of Cardiac Transplantation D. T. Tran1, Z. Tu2, C. Atkinson1, S. N. Nadig1. 1Microbiology & Immunology, Surgery, Medical University of South Carolina, Charleston, SC, 2Microbiology & Immunology, Medical University of South Carolina, Charleston, SC
3:05 PM	(160) The Evaluation of Coronary Artery Function during Normothermic Ex Situ Heart Perfusion X. Qi, S. Hatami, B. Tkachuk, M. Buchko, S. Bozso, D. He, S. Himmat, C. W. White, J. Nagendran, D. H. Freed. Surgery, University of Alberta, Edmonton, AB, Canada

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Primary Audience: BSTR
Secondary Audience: HTX, PATH, PEDS

Chairs: Alexander M. Bernhardt, MD and Karl B. Lemstrom, MD, PhD
 

6:00 PM	(429) Functional Assessment of DCD Hearts Following Normothermic Regional Perfusion Can Predict Post-Transplantation Contractility R. Ribeiro, J. S. Alvarez, E. Paradiso, F. Yu, M. B. Adamson, F. Foroutan, V. Bissoondath, M. Meineri, V. Rao, M. V. Badiwala. Cardiovascular Surgery, Toronto General Hospital, Toronto, ON, Canada
6:05 PM	(430) Hi1a, an ASIC1a Inhibitor, Significantly Improves the Tolerance of Donor Allografts to Ischaemia in a Rodent Model of DCD Heart Transplantation S. E. Scheuer1, L. Gao2, M. Hicks1, H. Chew1, A. Doyle2, J. Villanueva2, A. Jabbour1, G. King3, P. Macdonald1, K. Dhital1. 1St Vincent's Hospital, Darlinghurst, Australia, 2Victor Chang Cardiac Research Institute, Darlinghurst, Australia, 3Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
6:10 PM	(431) In Vivo Resuscitation, Perfusion and Transplantation of a Porcine Cardiac Allograft Donated after Cardiac Death A. Grant1, R. R. Gonzalez2, A. Klima1, A. Badiye3, A. Gardiner4, M. Thomas5, I. hernandez Schulman6, J. Hare7, A. Ghodsizad2, M. Loebe2. 1Miami Transplant Institute University of Miami, Miami, FL, 2Surgery, Miami Transplant Institute University of Miami, Miami, FL, 3Cardiology, Miami Transplant Institute University of Miami, Miami, FL, 4Veterinary Resources, University of Miami, Miami, FL, 5Department Veterinary Resources, University of Miami, Miami, FL, 6Interdisciplinary Stem Cell Institute, Department of Medicine, Division of Nephrology, Katz Family Division of Nephrology and Hypertension, University of Miami Leonard M Miller School of Medicine, Miami, FL, 7Interdisciplinary Stem Cell Institute, Cardiovascular Division, University of Miami Leonard M Miller School of Medicine, Miami, FL
6:15 PM	(432) Conditioned Medium from Mesenchymal Stem Cells Protects Vascular Grafts of Brain-Dead Rats against In Vitro Ischemia/Reperfusion Injury S. Korkmaz-Icöz1, P. Zhou1, Y. Guo1, S. Loganathan1, P. Brlecic1, T. Radovits2, M. Ruppert1, A. A. Sayour1, M. Karck1, G. Szabó1. 1Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany, 2Heart and Vascular Center, Semmelweis University, Budapest, Hungary
6:20 PM	(433) Gene Expression in Ex Vivo Perfused Porcine Hearts: Identification of a Molecular Injury-Repair Response 1, N. Herbers1, S. Hatami2, M. Mengel1, J. Nagendran2, D. H. Freed2, span style="text-decoration: underline">B. Adam1. 1Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada, 2Department of Surgery, University of Alberta, Edmonton, AB, Canada
6:25 PM	(434) Ghrelin, a Novel Growth Hormone-Releasing Peptide, Inhibits Inflammatory Response and Apoptosis during Ischemic Reperfusion Injury Following Murine Heart Transplantation N. Fukunaga1, R. V. Ribeiro1, V. Bissoondath1, F. Billia2, M. V. Badiwala1, V. Rao1. 1Cardiovascular Surgery, Toronto General Hospital, Toronto, ON, Canada, 2Cardiology, Toronto General Hospital, Toronto, ON, Canada

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Primary Audience: BSTR
Secondary Audience: LF/LTX, PATH

Session Summary: The pathologies of Chronic Lung Allograft Dysfunction (CLAD) have been recognized since 1984, yet their mechanisms and definitive treatments remain enigmatic. Indeed, there are multiple rival hypotheses as to the cause of CLAD. Is CLAD a final common pathway, an integration of pathobiologies, or are some pathways overriding? This symposium will describe the scientific evidence for some of these pathways.

Chairs: Sangeeta M. Bhorade, MD and Stijn E. Verleden, MD, PhD
 

7:00 AM	Immune Responses Cause CLAD Federica Meloni, MD, University of Pavia, Pavia, Italy
7:15 AM	CLAD is a Disease of Accelerated Aging John R. Greenland, MD, PhD, UCSF Medical Center, San Francisco, CA, USA
7:30 AM	Mesenchymal Stem Cells are the Cause of CLAD Vibha N. Lama, MD, MS, University of Michigan, Ann Arbor, MI, USA
7:45 AM	15-min Panel Discussion

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Primary Audience: ID, BSTR
Secondary Audience: HTX, LTX, MCS, PATH, PEDS

Chairs: Tobias Deuse, MD, PhD and Ignacio Echenique, MD
 

7:00 PM	(534) The Impact of Biomarkers in Predicting the Response to CD34+ Cell Therapy in Non-Ischemic Dilated Cardiomyopathy Patients G. Zemljic, M. Jaklic, A. Cerar, S. Frljak, G. Poglajen, B. Vrtovec. Advanced Heart Failure and Transplantation Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia
7:05 PM	(535) LVAD Therapy Induces Changes in Myocardial Glucose Metabolism and Clock Genes K. Dhar1, A. KC1, F. Qiu2, H. Basma1, J. Um3, D. Anderson1, B. Lowes1. 1Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 2Bio Statistics, University of Nebraska Medical Center, Omaha, NE, 3Surgery, University of Nebraska Medical Center, Omaha, NE
7:10 PM	(536) Sphingosine-1-Phosphate Receptor Agonist Fingolimod Reduces Myocardial Ischemia-Reperfusion Injury and Apoptosis Increasing Long-Term Left Ventricular Function after Heart Transplantation A. Rungatscher, D. Linardi, A. Naseer, R. Mani, S. Hoxha, G. B. Luciani, G. Faggian. Division of Cardiac Surgery, Department of Surgery, University of Verona, Verona, Italy

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Primary Audience: BSTR
Secondary Audience: HF/HTX, LF/LTX, PHARM
Session Summary: The goal of this symposium is to provide the audience with a deeper understanding of antibody-mediated mechanisms and potential downstream consequences of antibodies in transplantation. Presentations will discuss the basic science of immunology, the role of donor specific antibodies and emerging management strategies.

Chairs: Laurie D. Snyder, MD and Edward Horn, PharmD, BCPS
 

10:15 AM	The Pre-Transplant Alphabet Soup – MFI, C1Q, HLA Christine Falk, MD, Hannover Medical School, Hannover, Germany
10:30 AM	Seeing Ghosts? The Role of Non-DSA and Non-HLA in the Transplant Recipient Antoine Roux, MD, Hôpital Foch, Paris, France
10:45 AM	The Needles in the Haystack: Diagnostic Challenges in Antibody-Mediated Rejection Agnieszka Ciarka, MD, PhD, Catholic University of Leuven, Leuven, Belgium
11:00 AM	The Transplant Toolbox: Dealing with DSA Now and in the Future Miae Kim, PharmD, Brigham & Women's Hospital, Boston, MA, USA
11:15 AM	DEBATE: Photopheresis is Useful for Rejection Management (PRO) Peter Jaksch, MD, Medical University of Vienna, Vienna, Austria
11:30 AM	DEBATE: Photopheresis is Useful for Rejection Management (CON) Michael Shullo, PharmD, University of West Virginia, Morgantown, WV, USA
11:45 AM	15-min Panel Discussion

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Primary Audience: BSTR
Secondary Audience: LTX, PEDS, PATH

Chairs: Bart M. Vanaudenaerde, MSc, PhD and Stephen C. Juvet, MD, PhD, FRCPC
 

12:15 PM	(320) Development of a New Local Therapeutic Approach for BOS: Efficacy of Imatinib Loaded -antiCD44 Coated Gold Nanoparticles In Vitro and In Vivo F. Meloni1, R. Di Paola2, P. Morbini3, L. Pandolfi4, V. Frangipane4, E. Gugliandolo2, E. Cova5, M. Colombo6, D. Prosperi6, P. Vitulo7, G. Ferrario8, R. Fusco2, C. Pacini6, R. Siracusa2, S. Cuzzocrea2. 1Internal Medicine, University of Pavia, Pavia, Italy, 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy, 3Molecular Medicine, University of Pavia, Pavia, Italy, 4Respiratory Diseases, IRCCS San Matteo, Pavia, Italy, 5Pathology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, 6Department of Biotechnology and Bioscience, University of Milano Bicocca, Milan, Italy, 7Respiratory Disease Unit, IRCCS ISMETT, Palermo, Italy, 8Pathologysection Department of Molecular Medicine, University of Pavia, Pavia, Italy
12:30 PM	(316) B Cells Drive iBALT Formation in a Mouse Model of Chronic Lung Allograft Dysfunction N. F. Smirnova1, T. M. Conlon2, C. Morrone2, A. O. Yildirim2, O. Eickelberg1. 1PSCCM, University of Colorado - Anschutz Medical Campus, Aurora, CO, 2Comprehensive Pneumology Center, Munich, Germany
12:45 PM	(317) Linking CLAD in Lung Transplant Recipients after 3 Years Follow Up with Transplant Arteriosclerosis in Humanized Mice T. Siemeni1, A. Knöfel1, F. Ius1, J. Salman1, W. Sommer1, M. Avsar1, R. Poyanmehr1, C. Kühn1, C. Falk2, I. Tudorache1, A. Haverich1, G. Warnecke1. 1Hannover HTTG, Hannover, Germany, 2Hannover Transplant Immunology, Hannover, Germany
1:00 PM	(318) Pulmonary Antibody-Mediated Rejection (AMR) Accelerates Aging-Evidence from Whole Genome DNA Methylation Sequencing S. Agbor-Enoh1, F. Seifuddin1, M. Pirooznia2, M. Jang1, H. Valantine1. 1Genomic Research Alliance for Transplantation (GRAfT), Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, 2Genomic Research Alliance for Transplantation (GRAfT), Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD
1:15 PM	(319) Increased NKG2C+ Natural Killer Cells in Bronchoalveolar Lavage Precede CMV Viremia and Are Associated with CLAD or Death in Lung Transplant Recipients D. R. Calabrese1, T. Chong1, A. S. Wang1, J. P. Singer1, M. Gottschall2, S. R. Hays1, J. A. Golden1, J. Kukreja3, Q. Tang3, J. R. Greenland4. 1Department of Medicine, University of California San Francisco, San Francisco, CA, 2Department of Clinical Lab Medicine, University of California San Francisco, San Francisco, CA, 3Department of Surgery, University of California San Francisco, San Francisco, CA, 4Medical Service, VA Health Care System, San Francisco, CA
1:30 PM	(7) A Novel Injury Site-Targeted Complement Inhibitor Which Protects against Lung Transplant Ischemia Reperfusion Injury C. Li1, K. Patel2, P. Allen2, Z. TU1, J. Kilkenny1, C. Wallace1, S. Nadig1, S. Tomlinson1, C. Atkinson1. 1Departments of Microbiology and Immunology, and Surgery, Medical University of South Carolina, Charleston, SC, 2Department of Surgery, Medical University of South Carolina, Charleston, SC
1:45 PM	(321) Receptor Tyrosine Kinase Inhibitor Nintedanib as Treatment Option in Bronchiolitis Obliterans after Airway Transplantation C. Heim1, J. Mauer1, A. Kuckhahn1, J. Distler1, B. Spriewald1, M. Ramsperger-Gleixner1, M. Weyand1, S. M. Ensminger2. 1University of Erlangen, Erlangen, Germany, 2University of Luebeck, Lubeck, Germany