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Primary Audience: PHARM
Secondary Audience: HF/HTX, LF/LTX

Session Summary: This symposium will review management of comorbidities and primary care needs that affect heart and lung transplant recipients before and after transplant including diabetes, dyslipidemia, osteoporosis, psychiatric disorders, complimentary/alternative medicine, and immunizations/travel. Best practices and recent guideline recommendations will be presented for each topic. New and novel medications available and any pros or cons for use in the transplant population will be discussed.

Chairs: Patricia Ging, PharmD and Nicole L. Casciello, PharmD, MBA
 

10:30 AM	What to Do When the A1C is ‘BIGLY’: An Update on the Management of Post-Transplant Diabetes Jennifer L. Day, PharmD, Baptist Health Heart Failure and Transplant Institute, Little Rock, AR, USA
10:45 AM	Good Lipoproteins on Both Sides: Optimizing Treatment of Dyslipidemia and Obesity Jill C. Krisl, PharmD, Houston Methodist Hospital, Houston, TX, USA
11:00 AM	Skeletons in the Closet': Diagnosis, Prevention and Treatment of Osteoporosis David Iturbe, MD, Hospital Universitario Marques de Valdecilla, Santander, Spain
11:15 AM	'Stable Genius': Managing Mental Health After Transplant Melissa Sanchez, BSc, Hons, Royal Brompton & Harefield NHS Foundation Trust, Harefield, Middlesex, UK
11:30 AM	Combating 'Alternative Facts': Complementary and Alternative Medicine in Transplant Teena Sam, PharmD, Baylor University Medical Center, Dallas, TX, USA
11:45 AM	'Fake News': Immunization Practices and Travel Prophylaxis Michele Estabrook, MD, St. Louis Children’s Hospital, St. Louis, MO, USA
12:00 PM	15-min Panel Discussion

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Primary Audience: PHARM
Secondary Audience: HF/HTX, MCS

Chairs: Adam B. Cochrane, PharmD and Keyur B. Shah, MD
 

2:00 PM	(59) Omega-3 Suppresses Gastrointestinal Bleeding by Reducing Angiopoietin-2 Expression in LVAD Patients T. Imamura, A. Nguyen, D. Nitta, S. Kalantari, B. Smith, J. Raikhelkar, N. Narang, B. Chung, I. Ebong, L. Holzhauser, T. Fujino, C. Juricek, P. Combs, D. Onsager, T. Song, T. Ota, V. Jeevanandam, G. Sayer, G. Kim, N. Uriel. University of Chicago, Chicago, IL
2:15 PM	(60) Effect of Methylene Blue Administration on Vasoplegia Following Left Ventricular Assist Device Implantation A. Saha1, D. L. Jennings2, J. Sanchez1, A. Melehy1, M. Yuzefpolskaya3, P. C. Colombo3, M. A. Farr3, H. Takayama4, Y. Naka4, K. Takeda4. 1Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Department of Pharmacy, Columbia University Irving Medical Center, New York, NY, 3Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, NY, 4Department of Surgery, Division of Cardiac, Thoracic & Vascular Surgery, Columbia University Irving Medical Center, New York, NY
2:30 PM	(61) Comparative Efficacy of Bortezomib and Carfilzomib Desensitization Protocols in Highly Sensitized Cardiac Transplant Candidates M. Sobhanian1, J. Saltarrelli2, P. Weeks1, S. Nathan2, R. Radovancevic2, B. Kar2, I. Gregoric2. 1Memorial Hermann Hospital - Texas Medical Center, Houston, TX, 2The University of Texas Health Science Center at Houston, Houston, TX
2:45 PM	(62) Mycophenolic Acid Area under the Curve Monitoring via Limited Sampling Strategy in Pediatric Heart Transplant Recipients S. A. Crow, S. H. Dahl, J. N. Johnson. Mayo Clinic, Rochester, MN
3:00 PM	(63) Association between Cumulative Pre-Transplant Amiodarone Dose and Post-Transplant Outcomes after Heart Transplantation L. M. Lourenco1, K. Lang1, P. Simone1, S. Patel1, J. Powers2, T. Riley2, C. Murks2, B. Smith2, S. Kalantari2, J. Raikhelkar2, N. Sarswat2, G. Kim2, G. Sayer2, N. Uriel2. 1Pharmacy Services, University of Chicago Medicine, Chicago, IL, 2Cardiology, University of Chicago Medicine, Chicago, IL
3:15 PM	(64) Retrospective Nested Case Control Study of the Impact of Immunosuppression on Post Transplant Malignancy among Adult Heart Transplant Patients S. A. Crow, R. J. Bubik, N. L. Pereira, K. C. Mara, R. A. Dierkhising, S. S. Kushwaha. Mayo Clinic, Rochester, MN
3:30 PM	(65) Past is Not Prologue - Immune Function Assay Results as a Predictor of Malignancy Post-Heart Transplant (HT) T. Khuu1, M. Kamath2, M. Moore1, A. Salimbangon1, T. Daun1, A. Chang1, L. Sweet1, E. DePasquale2, A. Nsair2, R. Ardehali2, A. Baas2, M. Deng2, M. Cadeiras3, A. Ardehali4. 1Transplant Services, UCLA, Los Angeles, CA, 2Medicine, Cardiology, UCLA, Los Angeles, CA, 3Medicine, Cardiology, UC Davis, Davis, CA, 4Surgery, UCLA, Los Angeles, CA

Visit the ISHLT2019 Online Program Viewer to see the full abstracts from this session

Pharmacy and Pharmacology (Gardenia 1)
(PHARM)   Poster Numbers: 755-763

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Primary Audience: PHARM
Secondary Audiences: HF/HTX, LF/LTX, NHSAH

Session Summary: The purpose of this symposium is to review substances of abuse pre- and post-transplant. The symposium will focus on use of medications for pain and anxiety, smoking (nicotine and marijuana), and alcohol use. Speakers will present available evidence describing why these substances are harmful when used before and after transplant and offer guidance for cessation or therapeutic alternatives.

Chairs: Martin Zamora, MD and Vincent G. Valentine, MD
 

7:00 AM	‘Hurts So Good’: Analgesia Beyond Opioids Amanda Ingemi, PharmD, Sentara Norfolk General Hospital, Norfolk, VA, USA
7:15 AM	Q&A
7:20 AM	So, Light 'em if You've Got 'em - or Don't! Smoking Pre- and Post-Transplant Erik Verschuuren, MD, PhD, University Medical Centre Groningen, Groningen, Netherlands
7:35 AM	Q&A
7:40 AM	How Much is Too Much? Alcohol Use and Cessation Pre- and Post-Transplant Mary Amanda Dew, PhD, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
7:55 AM	Q&A

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Primary Audience: NHSAH, PHARM
Secondary Audience: HTX, LTX, PEDS

Chairs: Donna Hickling and Kyle Dawson, PharmD, MBA, BCPS
 

6:45 PM	(474) A Pilot Randomized Placebo Controlled Trial of Inhaled Beclomethasone after Community-Acquired Respiratory Viral (CARV) Infection in Lung Transplant Recipients (LTR) K. B. Bain1, K. A. Fester1, J. Iuppa2, K. Bakos1, B. Mittler3, K. Richardson3, P. Aguilar3, J. Alexander-Brett3, D. Byers3, H. Kulkarni3, E. Trulock3, C. Witt3, R. Yusen3, V. Puri4, D. Kreisel4, R. Hachem3. 1Pharmacy, Barnes Jewish Hospital, Saint Louis, MO, 2Pharmacy, University of Rochester Medical Center, Rochester, NY, 3Pulmonary & Critical Care, Washington University, Saint Louis, MO, 4Surgery, Washington University, Saint Louis, MO
6:50 PM	(475) Effects of INR Variability and Time in the Therapeutic Range on the Rates of Gastrointestinal Bleeding in Patients Supported by Left Ventricular Assist Devices A. Mardis1, M. Freiter2, B. Mierzejewski2, M. Adams3. 1Department of Pharmacy, Palmetto Health, Columbia, SC, 2College of Pharmacy, University of South Carolina, Columbia, SC, 3Department of Family and Preventive Medicine, University of South Carolina College of Medicine, Columbia, SC
6:55 PM	(476) Appropriate Management of Drug Interactions Results in Safe Use of Hepatitis C Therapies in Heart Transplant Recipients K. Boyle, R. E. Fowler, A. Pollack, C. Edmonds, J. Gray, J. Lindenfeld, K. Schlendorf. Vanderbilt University Medical Center, Nashville, TN

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Primary Audience: PHARM
Secondary Audience: MCS

Session Summary: This symposium will aim to review pharmacotherapy management of hematologic complications in transplant and MCS including neutropenia, thrombocytopenia, anticoagulation with direct oral anticoagulants (DOACs), hemoglobin optimization, and bleeding reversal.

Chairs: Bastian Schmack, MD and Kyle L. Dawson, PharmD, MBA, BCPS
 

7:00 AM	I've Got Friends with Low Platelets (and Neutrophils): Management of Cytopenias After Transplant Jennifer McDermott, PharmD, Spectrum Health, Grand Rapids, MI, USA
7:15 AM	Q&A
7:20 AM	Thicker than Blood: Using DOACs in Transplantation and MCS Sara Strout, PharmD, Johns Hopkins, MD, USA
7:35 AM	Q&A
7:40 AM	Ain't No Hemoglobin High Enough: Approaches to Hemoglobin Optimization and Bleeding Reversal Pre- and Post-Surgery Ian B. Hollis, PharmD, BCPS, University of North Carolina Medical Center, Chapel Hill, NC, USA
7:55 AM	Q&A

Visit the ISHLT2019 Online Program Viewer to see the full details for this session

Primary Audience: PHARM
Secondary Audience: MCS

Session Summary: ECMO presents unique drug dosing and medication management challenges. This symposium will discuss the approach to optimal pharmacotherapy management for ECMO patients with a focus on anti-infectives and anticoagulation. Anecdotes and clinical pearls for ECMO in special populations will also be discussed.

Chairs: Patricia Uber, PharmD and Charles Hoopes, MD
 

7:00 AM	Keeping Things Moving: Anticoagulation on ECMO Christopher Michaud, PharmD, BCPS, Spectrum Health, Grand Rapids, MI, USA
7:15 AM	Q&A
7:20 AM	What's My Vd Again? Drug Dosing on ECMO with a Focus on Anti-Infectives Haifa Lyster, MSc, Royal Brompton, Middlesex, UK
7:35 AM	Q&A
7:40 AM	ECMO and What Else? Approach to Management of ECMO in Special Populations Konrad Hoetzenecker, MD, PhD, Medical University of Vienna, Vienna, Austria
7:55 AM	Q&A