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A Big Bang in Barcelona: ESOT Congress 2017

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Javier Carbone, MD, PhD
Complutense University
Madrid, Spain

The European Society for Organ Transplantation Congress held in Barcelona on September 24-27, helped refine our knowledge of basic science and clinical concepts to improve transplantation in a holistic approach.

One interesting example of this was the session entitled, "The Devil's Advocate: a moderated controversy in basic science." During this session, a presentation of a basic science article was followed by a critical discussion with an 'opponent' and a general discussion with the audience. The first conference was "New insights in the priming of recipient's immune system: Donor dendritic cell-derived exosomes promote allograft-targeting immune response" by Adrian Morelli ('Defender', Pittsburgh, United States) and Gavin Pettigrew ('Opponent', Cambridge, United Kingdom). Following was the "Impact of microbiota on transplantation outcomes: The composition of the microbiota modulates allograft rejection" by Maria Luisa Alegre (Defender, Chicago, United States) and Heinz Zoller ('Opponent', Innsbruck, Austria).

Other examples of selected content in Basic Science were: "A CRISPR way to engineer the human genome" by Angelo Lombardo (Milan, Italy), "Genetic, epigenetic and cellular approaches to combat disease and aging" covered by Juan Izpisua (La Jolla, United States) and "hidden sensitization: the memory B cell repertoire" by Oriol Bestard (Barcelona, Spain).

Sun and Basic Science in Zell am See, Salzburg, Austria: Austrotransplant Congress 2017

I had the opportunity to attend this interesting meeting in a lovely place in Austria on October 18-20.

During this congress, Mahr Benedikt (Vienna) discussed natural killer cells targeting mature lymphocytes under inflammatory conditions by missing-self recognition. Resch Thomas (Innsbruck) reviewed Toll-Like Receptor 3 as a novel target for the prevention of ischemia-reperfusion injury in solid organ transplantation.

There was an interesting Basic and Translational Science Session, moderated by Thomas Wekerle (Vienna) and Rupert Oberhuber (Innsbruck). Eller Katrin reviewed the current status of distinct strategies for induction of tolerance in kidney transplantation including recent data and challenges observed during the ONE Study, which is evaluating cellular immunotherapy in solid organ transplantation. Mario Wiletel discussed the induction of tolerance by treatment with IL2/JES6-1 (anti-IL-2 monoclonal antibody) complexes. Nina Pilat-Michalek conversed the potential synergistic action of anti-IL6 with IL2/anti-IL2 complexes to promote transplantation tolerance with participation of regulatory T cells and antigen presenting cells. ■

Disclosure Statement: The author has no conflicts of interest to disclose.

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