Many thanks to Emily Stimpson, Christian Benden and Ed Horn (NHSAH, PEDS and Pharmacy Council Links Liaisons) for coordinating the focus content for this issue.

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Hopefully this is not a sign. The facts are: 1) Jim Theodore cared for his family, his patients and all of us; 2) he disappeared over ten years ago; and 3) technology continues to race ahead but requires communication and trust.

Paramount to all of this is planning, protocol development, review, prevention, performance improvement, reassessment and again, communication.

Communication—simple and direct, not only for us and the multidisciplinary teams we are all part of, but most importantly for the primary caregivers or patient's support system to understand. To understand truly, madly and deeply.

With all the different Englishes there is still the potential for mass confusion. Not to mention everyone's biases and, the new confounder (a by-product of rapid technological advancement), potential obstacles to the delivery of passionate and attentive care for the relief our patients that is, along with the biases, social media.

In the end, to prevent and minimize the undermining of our great successes, great stories and "fairy-tales" still boils down to good old-fashion English, I mean common sense.

Vincent Valentine, MD
Editor-in-Chief, ISHLT Links Newsletter


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Jim Theodore: A Pioneer in Lung Transplantation

by Vincent Valentine

The Junior Faculty and Trainee Council initiated the series, Transplant Greats, featuring the legends in the field of heart and lung transplantation. In the inaugural issue last month, our matriarch of heart transplantation, Sharon Hunt, was introduced. This month's issue presents you the next Transplant Great: Jim Theodore, the grandfather of transplant pulmonary medicine. Why? Because he has been fondly known as the "old man" by many of us and our patients. Why? Because he is easily linked with Sharon Hunt: just before he began his career at Stanford, he spent time in Dayton, Ohio. Why? Because he stood back from the spotlight, preferring no recognition (a lesson in and of itself), and because it has been a decade since his death without any commendation from us. Jim deserves this tribute as you will come to understand. His advice to young faculty: let your results speak for themselves. Read more →


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Disappearing Caregiver

by Pamela Combs

Caring for patients discharged on VADs can be overwhelming, and often the caregiver deems the designated responsibility as impossible to fulfill. Thus, the VAD team may notice the presence of the caregiver vanishing. What steps can the VAD team take to prevent the caregivers from disappearing?. Read more →

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Evolving Technology—A Single Center Perspective

by Dorothy Lockhart

Multidisciplinary planning with trust and communication is essential when implementing new technology or procedures in a highly complex patient population. Find out how this center developed a protocol that works for their team. Read more →


Social Media and Pediatric Lung Transplantation in the US

by George Mallory and Stuart Sweet

The parents of 10 year old Sarah Murnaghan, a child with cystic fibrosis in Philadelphia who had been waiting 18 months for lung transplant, ignited a media frenzy when they made public their concerns that allocation policies in the United States might prevent their child from receiving a transplant. Read more →

Fontan-Associated Liver Disease: Reversible with Cardiac Transplantation, or "Past the Point of No Return"?

by Kathleen Simpson and Melanie Everitt

While protein-losing enteropathy, systolic heart failure, and plastic bronchitis are well described complications of the Fontan procedure, there has been growing awareness of Fontan-associated liver disease. Many questions arise in terms of the impact of Fontan-associated liver disease on heart transplant mortality and the reversibility of the disease process after heart transplant. Read more →


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A Review of New Oral Anticoagulants: Some 'Factors' to Consider

by Jennifer Day

An increasing number of patients are being treated with the novel oral anticoagulants (NOACs), in lieu of the vitamin K antagonist, warfarin, for a variety of indications. Although quite promising in some aspects (predictable effect without need for monitoring, fewer food and drug interactions, shorter plasma half-life, and improved efficacy/safety ratio), these drugs present a new set of challenges (no reversal agent, lack of evidence in patients with valves/devices, dependence on strict compliance with dosing), which require careful consideration in the already tenuous course of transplant and VAD patient populations. Read more →

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Vaccines: the First Line of Infection Prophylaxis

by Amanda Ingemi

Vaccine administration is one of the most effective ways of preventing diseases, specifically influenza, herpes zoster, pneumococcal disease, and others. This disease prevention is especially important in the transplant patient population. Vaccines are can be of later consideration and it can be difficult to keep up-to-date with recommendations that appear to be constantly in flux, especially since there is a lack international consensus from varying bodies of government. Read more →

Pharmacists take prominent role at the International Society of Heart and Lung Transplant 33rd annual meeting and scientific sessions in Montreal

Patricia Ging and Mike Shullo, from the European Journal of Hospital Pharmacists

There was a real buzz after the pharmacy symposium at the International Society of Heart and Lung Transplant (ISHLT) annual conference this year in Montreal, with the audience and speakers breaking into groups to discuss aspects of the challenging real life case that had been presented as part of the Pharmacy and Pharmacology council's 'Lifecycle Journey' series. Read full article →


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Once Upon A Time

by Kate Gould

Once upon a time there was a person who had a bad heart (or lungs). He was very ill until a nice doctor came along and said she could make him better by taking out his old heart and plumbing in a new one. The operation took place, there were no complications and the person went back to living a normal life and lived happily ever after. Read more →


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The 34th Annual Meeting & Scientific Sessions will be held April 10-13, 2014 at the Manchester Grand Hyatt San Diego. Please note that the main meeting begins on Thursday, April 10, one day later than usual, and concludes at mid-day on Sunday, April 13. Please note this change of dates and makes plans accordingly. There will be three ISHLT Academies held on Wednesday, April 9th: Core Competencies in Basic and Translational Science, Core Competencies in Heart Failure and Cardiac Transplantation, and Core Competencies in Nursing, Health Science, and Allied Health.

Also, on Monday and Tuesday, April 7-8, ISHLT will conduct two Academies related to MCS: Core Competencies in Mechanical Circulatory Support and a Master's Course in Mechanical Circulatory Support. These will be held at the Loews San Diego Bay Resort in Coronado, California. Those wishing to attend either of the MCS Academies must make hotel reservations at the Loews for those 2/3 nights as rooms for this are not available at the Annual Meeting HQ hotel.

Registration and housing for the Annual Meeting and the Academies will be available on October 1, 2013. Check the ISHLT web site for details.

The Abstract Submission Site will be live on September 9, 2013 at Abstract Submission deadline is November 15, 2013 at 11:59 PM EST.

International Traveling Scholarships

The next application deadline for an International Traveling Scholarship award is December 1st. The ISHLT Travelling Scholarship Awards were established to facilitate the exchange of knowledge and techniques regarding heart and lung transplantation and the treatment of end stage heart and lung failure and to build relationships between individuals, institutions, and countries. Read more →

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ICAAC 2013

September 10-13, 2013, Denver, Colorado, USA

ICAAC, the premier conference on antimicrobial agents and infectious diseases, showcases the latest-breaking science and lectures from top researchers from around the world. With over 60% of its attendees living outside of the United States, ICAAC provides a rare opportunity to bring together the field's foremost leaders to discuss the state of infection control and prevention on a global scale. Can't attend ICAAC 2013? Register today for online access to 126 sessions from the leading infectious diseases and antimicrobial agents conference in the world, ICAAC 2013. New this year! ICAAC 2013 now offers a track dedicated to transplantation infectious diseases. With ICAAC Online you can watch this year's presentations discussing solid organ transplantation, hematopoetic stem cell transplantation, donor-derived infections, immunosuppression-related infections, and more. Earn AMA PRA Category 1 Credits™, view 1,800 conference abstracts, and tour the Digital Poster Hall. Visit for more information.

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LAUGHING LINKS: You Just Gotta Laugh

by LeAnn Thieman

Statistics show that little kids laugh 400 times a day. One study showed that grownups laugh only eleven, and yet another said only four...and we've all had shifts when we couldn't even meet that quota! Proverbs tells us, "Laughter is good medicine, but a broken spirit dries the bones." Now there is medical evidence to corroborate that theory. Volumes are written today on the therapeutic benefits of laughter. Read more →

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Interesting, Inspiring and Intriguing Links from Around the Globe

Hot topics in organ transplantation this month include stories from the United Kingdom, South Africa, the United States, Brazil, and Ireland. Read more →

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ISHLT Members in the News

Some of our ISHLT members from all over the world have been found in the news this month, including Alanna Morris, Sam Gidding, Christian Pizarro, Rajat Walia, Michael Borkon, Nirav Raval, Andrew Savage, Leway Chen, Frank Downey, Alec Patterson, Robert Higgins and Bryan Whitson from the United States, John Mullen, Holger Buchholz, and Jamil Bashir from Canada, Timmy Au from Hong Kong, and Christof Schmid from Germany. Read more →

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English, Communication and Confusion

by Vincent Valentine

When examining our performances as healthcare providers we follow the premise that there is little success without failure. We don't intentionally fail, but we do make mistakes. When there is a problem or a consequence we must act and doing nothing at times may be a prudent part of the act. We improve ourselves through morbidity and mortality conferences and with quality assessment and performance improvement plans. We also heed the advice of our great American and Communicator, Benjamin Franklin, "an ounce of prevention is worth a pound a cure." Read more →

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adjective: continuing without interruption; ceaseless; unending.

The privative prefix in-, meaning not, combines with the Latin root cessare which means to stop or cease, giving us the word incessant. Synonyms include interminable, relentless, and unremitting. Antonyms include occasional, irregular, intermittent, sporadic, and erratic.

Incessant, continuous and continual are close synonyms. Distinguishing continuous and continual from incessant is a sign of a careful user of the language. Continuous means unbroken and is passive. Incessant means unceasing and is active. Railroad tracks and highways are continuous. Background music in elevators and malls is continuous for those who don't mind it and is incessant for those who become irritated by it and ends up constant and never-ending. Continual means happening repeatedly at short intervals. There are continual e-mail reminders about the article you need to review. Also there is the continual ring tone of your smart phone until you answer it. On the other hand there is the continuous rotation of the earth, which might quite actively be incessant, we hope.


Vincent G Valentine, MD, Editor-in-Chief

Editorial Staff

"The best and most beautiful things in the world cannot be seen or even touched. They must be felt with the heart."

— Helen Keller

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Disclaimer: Any opinion, conclusion or recommendation published by the Links is the sole expression of the writer(s) and does not necessarily reflect the views of the ISHLT.