THIS MONTH'S FOCUS:

INFECTIOUS DISEASES, MCS and BASIC SCIENCE

(PDF VERSION)


Many thanks to Middy Estabrook, Macé Schuurmans, and Evgenij Potapov (ID and MCS Council Links Liaisons) for coordinating the focus content for this issue.




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VINCENT'S SUMMER SENSE:

In this "hot stuff" summer issue for those of us in the Northern Hemisphere as we shout "get off of my cloud," Dr Howard Eisen provides us some wisdom from gene expression profiling to the electronic medical record. Dr Hannan, Dr Morrissey as well as Dr Koval and others share with us an update, the troubles, and the road to take for our journey in combating the incessant siege from germs that get in the way of our efforts. On wondering if an emergency prepared for is not an emergency, Drs Vierecke's and Potapov's article emphasizes the importance of education and preparedness when our patient's mechanical circulatory device is in trouble or stops altogether. It's only the beginning. Among others, there are a few things simply outta this world and some others will make you laugh. However, in the end, for your "satisfaction," we have our very own "midnight rambler" and "respectable" John Dark with his editorial for your "emotional rescue" which will most assuredly give you, "The Big Chill."

Vincent Valentine, MD
Links Editor



IN THE SPOTLIGHT:



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Adventures in Translational Medicine: Gene Expression Profiling and the Electronic Medical Record

Howard Eisen

How has a test using changes in the expression of a set of genes in peripheral blood mononuclear cells—in the space of less than a decade—been incorporated into the routine laboratory tests that we use to manage our patients? And what does the future hold for the assessment of gene expression in the management of transplant patients? Read more...



FOCUS ON INFECTIOUS DISEASES:



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Infectious Diseases Update on IMACS

Margaret Hannan

The ID council continues to work with the IMACS registry to streamline the variables collected and develop a support structure for monitoring and validating these variables. Read more...



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The Trouble with Driveline Infections

Christine Koval, Lucy Thuita, Nader Moazami, Maria Mountis, and Eugene Blackstone

Driveline infections—a "systems" problem, from patients to physicians and surgeons, from antibiotics to hospital (microbiome), from bedside nurse to all involved down to the long-term care facilities. Pseudomonas, MRSA, and fungal infections should not be a surprise to anyone. Everyone plays a role, everyone is responsible or at least feels responsible. Read more...


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Universal Prophylaxis or Bio-marker Guided Antifungal Therapy: Which Road to Take?

Orla Morrissey

Invasive aspergillosis (IA) is a major cause of mortality in patients undergoing allogeneic stem cell transplantation (SCT) or chemotherapy for acute leukaemia, due mainly to the limited ability of culture and histology to make an accurate or early diagnosis. Consequently, clinicians rely on empiric antifungal therapy (EAFT) whenever IA is suspected or prevention through antifungal prophylaxis. Whilst these strategies have been successful in reducing IA-related mortality they have a number of limitations including drug interactions, emerging antifungal resistance, breakthrough invasive fungal infections (IFI) and overtreatment with expensive and toxic antifungal drugs. Read more...



FOCUS ON MECHANICAL CIRCULATORY SUPPORT:



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Mechanical Circulatory Support: Generating Consensus for Emergency Procedures

Juliane Vierecke and Evgenij Potapov

Because of the shortage of donor hearts for transplantation the numbers of VAD implantations and the number of patients living at home with a VAD are growing every year. In Germany approximately 1000 patients with VADs of different kinds are living at home. Read more...



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LAUGHING LINKS

While some of the newsletter's features are intended to inform or to network our members (with a bit of entertainment value sometimes too), Laughing Links is meant ONLY to give you a chuckle. We hope that it becomes the part you click on first as a way to lift the haze from your brain after a long day in the operating room or the clinic. Feel free to write in with humorous ideas, links from the media or YouTube, or just a good joke you've heard recently (assuming it is printable). Enjoy! Read more...



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OUTTA THIS WORLD LINKS

Interesting, Inspiring and Intriguing Links from Around the Globe

This month, learn about half-Japanese twin sisters who both survived double lung transplants to become global advocates for organ donation. Get an in-depth update on Sarah Murnaghan, the 10-year-old Pennsylvania girl who successfully underwent double-lung surgery after initially being denied an adult donation. Read the heartwarming story about a magistrate from Sydney, Australia, who underwent a successful heart transplant and is now awaiting a liver transplant. And ponder these questions: Should you be able to sell your organs? Should it be legal? Do you own yourself? Would you accept DNA from a murderer? Read more...



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TATTLING LINKS

ISHLT Members in the News

Several ISHLT members have made it into various news sources this month, including Jayan Nagendran (director of research for cardiac surgery at University Hospital and the Mazankowski Alberta Heart Institute), Christopher Almond (a cardiologist in the Heart Transplant Program at Boston Children's Hospital, and Andreas Zuckermann (director of Cardiac Transplantation at the Medical University of Vienna in Vienna, Austria). Read more...



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ANNOUNCEMENT:

NEW JHLT Impact Factor Released for 2013

The 2012 Journal Impact factors were released on June 20, 2013 and the Journal of Heart and Lung Transplantation has once again made substantial gains in prestige. The 2012 Impact factor is 5.112 (up from 4.332 last year). Read more...



ANNOUNCEMENT:

International Traveling Scholarship Awards

The next application deadline for an International Traveling Scholarship award is August 1st. The ISHLT Travelling Scholarship Awards were established to facilitate the exchange of knowledge and techniques regarding heart and lung transplantation and the treatment of end stage heart and lung failure and to build relationships between individuals, institutions, and countries. Read more...



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EDITOR'S CORNER

You Can't Always Get What You Want

John Dark, Senior Links Editor

Marvel of the Digital Age, Wonder of the Internet.... Thanks to those nice people at Apple, or Microsoft, and lots of others, I can sit at my desk in grey, moist, cool England (yes, summer again) and apparently be immersed in excitement anywhere in the globe. Read more...




Contact

Vincent G Valentine, MD, Editor-in-Chief
vgvalent@utmb.edu

Editorial Staff


"A child who is protected from all controversial ideas is as vulnerable as a child who is protected from every germ. The infection, when it comes—and it will come—may overwhelm the system, be it the immune system or the belief system."

— Jane Smiley

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Disclaimer: Any opinion, conclusion or recommendation published by the Links is the sole expression of the writer(s) and does not necessarily reflect the views of the ISHLT.