email icon  Email     printer icon  PDF

spotlight  IN THE SPOTLIGHT:

ISHLT 2013 Plenary Sessions

Schedules and Highlights




links image
Photo credit: © Lionel Humbert, Palias des congrès de Montréal

Thursday, April 25, 2013
Opening Plenary Session
8:00 AM - 10:00 AM, Room 517CD


8:00 AM:  Welcome/Program Chair Report
Allan R. Glanville, MBBS, MD, FRACP
St. Vincent's Hospital, Sydney, NSW, Australia


8:05 AM:  President's Report
David O. Taylor, MD
Cleveland Clinic, Cleveland, Ohio, USA


8:15 AM:  Thoracic Registry Report
Josef Stehlik, MD, MPH
University of Utah School of Medicine, Salt Lake City, Utah, USA


8:30 AM:  IMACS Registry Report
James K. Kirklin, MD
University of Alabama at Birmingham, Birmingham, Alabama, USA


8:40 AM:  FEATURED ABSTRACT: (2) Two-Year Outcomes in the Destination Therapy Post-FDA-Approval Study with a Continuous Flow Left Ventricular Assist Device: A Prospective Study Using the INTERMACS Registry; U.P. Jorde,1 S.S. Khushwaha,2 A.J. Tatooles,3 Y. Naka,1 G. Bhat,3 J.W. Long,4 D. Horstmanshof,4 R.L. Kormos,5 J.J. Teuteberg,5 M.S. Slaughter,6 E.J. Birks,6 D.J. Farrar,7 S.J. Park.2 1Columbia University Medical Center, New York, NY; 2Mayo Clinic, Rochester, MN; 3Advocate Christ Medical Center, Oak Lawn, IL; 4Integris Baptist Medical Center, Oklahoma City, OK; 5University of Pittsburgh Medical Center, Pittsburgh, PA; 6University of Louisville, Louisville, KY; 7Thoratec Corporation, Pleasanton, CA.


8:55 AM:  INVITED LECTURE: The Human Microbiome: What Is It, How Do We Measure It, What Does It Mean For Thoracic Transplantation?
links imageRonald G Collman, MD
University of Pennsylvania School of Medicine, Philadelphia, PA, USA

In this lecture, clinicians and investigators will understand what is meant by the "human microbiome" and what it means for transplantation science. Dr Collman will focus on 4 objectives: (1) to describe what is meant by the "microbiome", and the emerging tools used to investigate it; (2) highlight current knowledge of the human respiratory tract microbiome in health and in selected lung disease including lung transplantation; (3) show how the microbiome in other sites, such as gut, can influence cardiac and pulmonary disease including transplantation; (4) identify potential future applications for these approaches including diagnostic or monitoring purposes.


9:20 AM:  FEATURED ABSTRACT: (3) Longitudinal Holistic Profiling of the Lung Transplant Microbiome; D. Willner,1 N.A. Ab-Ghani,1 S. Yerkovich,2,3 M.E. Tan,2,3 P.M. Hopkins,2,3 D.C. Chambers,2,3 P. Hugenholtz.1 1Australian Centre for Ecogenomics, University of Queensland, St. Lucia, QLD, Australia; 2School of Medicine, University of Queensland, Herston, QLD, Australia; 3Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, QLD, Australia


9:35 AM:  PIONEER LECTURE: Cardiac Replacement, A Journey Outside The Box
links imageJack G Copeland, MD
University of California San Diego,San Diego, California, USA

The Pioneer in Transplantation award is bestowed every other year to an ISHLT member who is recognized for their landmark contributions as a pioneer in the field of heart and/or lung transplantation. This year's recipient, Jack G Copeland, MD, will take us through the journey of cardiac replacement, looking at risk taking in medicine and defining a pioneer by the past selections ISHLT has made. Dr Copeland will discuss the many individuals who were influential in his professional career, and give us insight into the Total Artificial Heart, past and present.



Friday, April 26, 2013
Plenary Session: How To Succeed When The Right Ventricle Fails
10:00 AM - Noon, Room 517CD

Session Summary: The right ventricle is often held accountable for morbidity and mortality in patients with advanced heart and/or lung disease. Moreover the right ventricle is frequently blamed for poor outcomes seen in patients receiving left ventricular assist device or heart transplantation. This session will provide the participant with a better understanding of right ventricular structure, function and physiology; how to evaluate right ventricular function in health and disease; and importantly management of right ventricular failure both through medical and surgical/device options.

10:00 AM: INVITED LECTURE: Right Ventricular Structure And Function In Health And Disease
links imageAndrew N Redington, MD, FRCP(C), FRCP(UK)
The Hospital for Sick Children
Toronto, Ontario, Canada

Dr Redington's talk will address normal myocardial structure and function, and the pathophysiology of failure in the normotensive and hypertensive right ventricle. Special emphasis will be placed on right-left heart interactions and possible approaches to modifying them for therapeutic benefit.


10:25 AM:  INVITED LECTURE: Clinical Assessment And Imaging
links imageDavid Langleben, MD
Jewish General Hospital, Montréal, Québec, Canada

Dr Langleben will focus on the physiology of the failing right ventricle and how this can be assessed by means of imaging, and how this translates to the clinic.



10:45 AM:  INVITED LECTURE: The Failing Systemic Right Ventricle
links imageDaniel Bernstein, MD
Stanford University, Stanford, California, USA

Dr Bernstein will describe several models of RV pressure and volume overload which have allowed us to evaluate RV remodeling as it progresses from the sub-acute to the chronic state, and to uncover the molecular mechanisms of the progression to RV failure. These data provide impetus for the development of new therapeutics aimed at the failing RV as well as potential biomarkers for early detection of adverse RV remodeling.


11:05 AM:  INVITED LECTURE: Medical Management
links imageJohn Granton, MD
University of Toronto, Toronto, Ontario, Canada

Right ventricular function correlates is the major cause of morbidity and mortality in patients with pulmonary arterial hypertension. In the absence of prospective studies, treatment of right ventricular failure must rest upon physiological principles. This lecture will build upon the knowledge gained in the previous presentation and lead to the development of the key principles of managing the patient with RV failure. Reducing RV afterload, protecting coronary blood flow, minimizing myocardial oxygen demands and resolving adverse RV-LV influence will be the key points of discussion.


11:25 AM:  INVITED LECTURE: Surgical Approaches, Devices and Transplant
links imageMartin Strueber, MD
Heart Center Leipzig, University Leipzig, Leipzig, Germany






11:45 AM  FEATURED ABSTRACT: (208) Left Ventricular Assist Device in Right Ventricular Failure; P. Parwani, B.M.P. Gowd, R. Nahar, C. Statz, D. O'Sullivan, N. Chomick, J. Radojevic, J. Gluck, J. Hammond, D. Wencker. Cardiology, Hartford Hospital, Hartford, CT



Saturday, April 27, 2013
Plenary Session: From Bench to Bedside
9:45 AM - Noon, Room 511

Session Summary: The final plenary session on Saturday represents one of the clear highlights of the meeting in Montreal and one you will miss at your peril. The session opens with great examples of translational science from the Society represented by two consensus reports on major areas in cardiac transplantation namely primary graft failure and a review of listing criteria based on a thorough review of the latest data. Marlene Rabinovich, one of our major invited speakers with a fantastic reputation throughout the scientific world, will then illustrate how basic research on BMPRII is offering new targets for much needed therapy in PAH in classic bench to bedside story. She will be followed by Mary Amanda Dew presenting novel data on recognizing the importance of mental health as well as physical health in all aspects of the Society's Interests. The session ends in a flourish with a grand debate on an extended role of VAD implantation in acute heart failure by two of the Society's most respected daughters. This plenary is a true synthesis of many facets of translational science at its best.

9:45 AM:  Awards Presentations
Duane Davis, MD, ISHLT Grants & Awards Committee Chair


10:00 AM:  ISHLT Consensus Report: Primary Graft Dysfunction (PGD) in Heart Transplantation
links imageJon Kobashigawa, MD
Cedars Sinai Medical Center, Los Angeles, California, USA

Dr Kobashigawa's lecture will focus on defining PGD after heart transplantation, assessing donor risk factors for the development of PGD, and assessing the treatment of PGD.



10:08 AM:  ISHLT Consensus Report: 2013 Heart Transplantation Listing Criteria
links imageMandeep R Mehra, MD
Harvard Medical School, Boston, Massachusetts, USA

Dr. Mehra will focus his lecture on a review of listing criteria based on a thorough review of the latest data.



10:15 AM:  INVITED LECTURE: BMPR2: From Mutation to Manipulation
links imageMarlene Rabinovitch, MD
Stanford University School of Medicine, Stanford, California, USA

Dr Rabinovitch will be discussing a number of potential therapies, ready for the clinic, that are based upon uncovering the pathway that is mutated and/or dysfunctional in patients with idiopathic pulmonary hypertension.


10:40 AM:  FEATURED ABSTRACT: (363) Survival in Pulmonary Arterial Hypertension Patients Awaiting Transplant; M. Gomberg-Maitland,1,8 C. Glassner-Kolmin,1 S. Watson,2 R. Frantz,3,8 M. Park,4,8 A. Frost,5 R. Benza,6,8 F. Torres.7,8 1Department of Medicine, University of Chicago, Chicago, IL; 2Department of Health Studies, University of Chicago, Chicago, IL; 3Mayo Clinic College of Medicine, Rochester, MN; 4Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; 5Department of Internal Medicine, Baylor College of Medicine, Houston, TX; 6Department of Medicine, Allegheny General Hospital, Pittsburgh, PA; 7Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; 8Scientific Council on Pulmonary Hypertension, International Society for Heart and Lung Transplantation, Addison, TX.


10:55 AM:  INVITED LECTURE: The Mind Matters
links imageMary Amanda Dew, PhD
University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA

Dr Dew will describe the impact of mental health or lack thereof on all that we do and try to achieve via a systematic review on psychological distress in transplant recipients.


11:15 AM:  FEATURED ABSTRACT: (364) Frailty Index Predicts Mortality but Not Rehospitalization after Destination Left Ventricular Assist Device; S.M. Dunlay,1 S.J. Park,2 L.D. Joyce,2 R.C. Daly,2 J.M. Stulak,2 S.M. McNallan,3 V.L. Roger,1 S. Kushwaha.1 1Internal Medicine, Cardiology, Mayo Clinic, Rochester, MN; 2Cardiothoracic Surgery, Mayo Clinic, Rochester, MN; 3Health Sciences Research, Mayo Clinic, Rochester, MN


11:30 AM:  The President's Debate:

VAD support leads to recovery
Partial support works?
Heart failure patients should be implanted earlier?

This grand debate will focus on the extended role of VAD implantation in acute heart failure by two of the Societies' most respected daughters.

links image PRO:
Emma Birks, FRCP, PhD
University of Louisville
Louisville, KY, USA

links image CON:
Mariell Jessup, MD
University of Pennsylvania
Philadelphia, PA, USA